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The Ultimate Guide to NAD IV Therapy Side Effects

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Dr. Hardik Soni

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Experience the Transformative Power of NAD Therapy with Peace of Mind

NAD IV therapy has taken the wellness world by storm, offering incredible benefits like boosted energy, improved mood, slowed aging, and relief from chronic conditions. But before booking your first NAD IV session, it’s normal to have some questions about possible side effects.

In this complete guide, we’ll give you an in-depth look at everything you need to know about NAD IV therapy side effects. You’ll learn what side effects are most common, how long they typically last, who is more likely to experience them, and how to minimize any discomfort. We’ll also cover key safety information on who should avoid NAD IV treatments altogether.

Read on to learn all about maximizing the incredible benefits of NAD therapy while minimizing any potential for side effects.

What is NAD Therapy?

NAD therapy involves intravenous infusion of nicotinamide adenine dinucleotide (NAD), a vital coenzyme found in all living cells. NAD plays a key role in energy production, cellular health, and many vital body processes.

NAD levels naturally decline with age, contributing to the effects of aging. Research shows NAD IV therapy can restore depleted levels, providing powerful anti-aging and restorative benefits.

Benefits of NAD therapy include:

  • Increased energy, mental clarity and focus
  • Improved mood and motivation
  • Reduced anxiety and addiction cravings
  • Enhanced athletic performance and recovery
  • Neuroprotective effects to slow brain aging
  • Relief from chronic fatigue and pain conditions
  • Antiviral effects to combat illness
  • Greater endurance, stamina and resilience
  • Slowing effects of aging throughout the body

NAD IV therapy shows tremendous promise for health optimization, disease treatment and prevention, anti-aging, and overall well being.

Experience the Benefits of NAD IV therapy at Ethos Aesthetics + Wellness. Schedule Your Consultation Today!

Frequently Reported Side Effects

The majority of patients who undergo NAD IV therapy find it to be gentle with minimal side effects. However, some temporary side effects can occur either during or shortly after receiving the infusion. These typically resolve within a few hours or days on their own. 

The most commonly reported NAD IV side effects include:


One of the most common potential side effects of NAD IV therapy is nausea or an upset stomach. Some patients report feeling queasy or having gastrointestinal discomfort during or after their session. The nausea is usually mild and goes away on its own within a few hours. Let Dr. Soni knows if you experience significant nausea so he can adjust your dosage or infusion rate.


Some people feel wiped out or tired following their NAD IV treatment. This fatigue may start during the infusion or develop over the next day or two. It’s usually temporary, lasting one to two days at most. Plan for some downtime after your appointment so you can rest. The tiredness should resolve as your body adjusts to the effects of the NAD.


Headaches are another possible side effect reported by some NAD IV therapy patients. The headaches can develop during or in the hours following treatment. They are generally mild and dissipate within a day or so. Stay well hydrated before and after your infusion to help minimize headaches. Alert us if headaches persist or worsen.

Stomach Pain or Cramping

In addition to nausea, some people experience abdominal discomfort like gas, bloating, or cramps during or after NAD therapy. Stomach issues are usually temporary and not severe. Let Ethos Aesthetics + Wellness know if you have ongoing or severe abdominal pain.


Feeling lightheaded or dizzy is an occasional side effect of NAD IV therapy for some patients. The dizziness is often mild and passes quickly. Rise slowly after your infusion to avoid dizziness. Be sure to alert us if you have vertigo or feel faint.


In rare cases, an upset stomach from NAD IV therapy may progress to vomiting. This is more likely if nausea is significant during the infusion. Vomiting may not occur until a few hours after treatment. We can adjust the dose to help avoid vomiting.

Tenderness or Swelling at Injection Site

Some people experience localized irritation where the IV line was inserted, like tenderness, redness, or swelling. This should resolve within a day or two. Use a cool compress on the site for comfort. 

Brain Fog

A small subset of patients report feeling somewhat spaced out or mentally cloudy for a day or two after NAD IV therapy. However, this brain fog is temporary and clears up quickly as the body adjusts. Stay well hydrated after treatment to minimize brain fog.

Muscle Fatigue or Cramping

Some people notice muscle tiredness, weakness, or cramping, often starting the day after treatment. Massage or heat therapy can provide relief. Muscle issues typically resolve within 48 hours. Inform Dr. Soni if muscle symptoms concern you.

Learn How Dr. Soni Ensures Your Comfort and Safety During NAD IV therapy. Book Your Session Now!

How Long Do NAD IV Therapy Side Effects Last?

The good news is that the vast majority of potential NAD IV side effects are temporary and resolve within a few hours to days after treatment. Most people start to feel back to normal within 24 hours.

Side effects like nausea, dizziness, headache, and fatigue generally dissipate completely within 1-3 days at most. Local injection site irritation improves quickly, within 12-48 hours.

More severe side effects like vomiting or severe stomach pain are very rare. But if experienced, we may adjust or discontinue your NAD therapy until symptoms resolve.

There are no reported long-term side effects associated with NAD IV therapy when performed by an experienced provider using proper protocols. The therapy has an excellent overall safety profile.

Who is More Prone to NAD IV Side Effects?

Research shows certain groups may be slightly more likely to experience temporary side effects from NAD IV therapy:

GroupSide Effect Risks
Those receiving their first ever NAD infusionYour body needs time to adjust to the effects of NAD. Side effects are most common with the initial session.
Individuals who normally experience motion sicknessPeople prone to motion sickness seem to have a higher likelihood of nausea or dizziness.
Patients on certain prescription medicationsSome medications may interact with NAD. Let your provider know about all supplements and prescriptions you take.
Those with pre-existing nausea or migrainesIf you already experience frequent nausea or headaches, you may be more susceptible to these side effects from NAD IV therapy.
People with chronic fatigue or muscle issuesThose with ME/CFS or fibromyalgia may be more likely to experience exacerbated tiredness or muscle pain.
Anyone significantly sleep deprivedLack of quality sleep can make you more prone to fatigue, headaches, and nausea from any therapy.

Can Side Effects from NAD IV Therapy be Avoided?

While most patients tolerate NAD IV well, it is possible to minimize potential side effects:

  1. Stay well hydrated before and after your infusion to prevent side effects like headache and dizziness. Drink at least eight 8-oz glasses of water the day before and after your session.
  2. Eat something light an hour or two before your appointment to avoid low blood sugar. Have a small snack after.
  3. Avoid alcohol, caffeine, and an empty stomach as these can worsen side effects.
  4. Take it easy after your infusion. Cancel strenuous exercise and rest to manage fatigue.
  5. Wear sunglasses on bright days to avoid light sensitivity.
  6. Use ginger, peppermint, or anti-nausea medications as needed for nausea.
  7. Consider prescription anti-nausea medication if you have a history of severe motion sickness.
  8. Discuss your full medical history with us so we can take precautions and adjust dosing if needed.
  9. Speak up during your infusion if you start to feel unwell so the dose can be adjusted.
  10. Arrange for a ride home in case you experience dizziness or fatigue afterwards.

Optimize Your NAD IV therapy with Expert Guidance. Minimize Side Effects and Maximize Benefits at Ethos Aesthetics + Wellness

Are There Any Serious Risks or Dangers of NAD IV Therapy?

Current research indicates NAD IV therapy is extremely safe when performed by a qualified experienced practitioner. There are no documented cases of serious adverse events or long-term side effects.

However, there are some precautions to be aware of:

  • Avoid NAD if pregnant or breastfeeding, as effects are unknown.
  • Those with severe heart conditions should use caution due to potential blood pressure changes.
  • People with glucose-6-phosphate dehydrogenase deficiency (G6PD) should avoid NAD therapy due to complications seen in mouse studies. Human effects unknown.
  • Avoid combining NAD IV therapy with alcohol consumption due to potentially dangerous interactions.

Always provide your full medical history to the provider so proper precautions can be taken if you have any health conditions or take prescription medications. For most people, NAD IV therapy performed by an expert provider is extremely low risk.

Experience the Benefits of NAD IV Therapy Without Worrying About Side Effects

Now that you understand the most common side effects of NAD IV therapy and how to minimize them, you can proceed confidently. While no medical treatment is completely free of potential side effects, NAD has an outstanding safety profile when done properly.

At Ethos Aesthetics + Wellness, your comfort and safety are our absolute priority. We will take all appropriate precautions and adjust dosing to make your NAD experience as pleasant as possible. You’ll find our warm, luxurious office and skilled staff provide the ideal setting for your NAD IV therapy.

Don’t wait to enjoy the incredible advantages of this cutting-edge treatment! Contact Ethos Aesthetics + Wellness today to schedule a consultation and get started. Our knowledgeable team is here to answer your questions, discuss your health goals, and help you determine if NAD IV therapy is a good fit.

Dr. Hardik Soni

MD, Founder/Lead Physician

About Dr. Hardik Soni

Dr. Hardik Soni is the founder and Medical Director of Ethos Aesthetics + Wellness. His primary focus is on minimally invasive and non-invasive cosmetic procedures including botulinum injection (Botox and Dysport), dermal fillers (Juvederm, Restylane, Radiesse), laser hair removal, chemical peels, and laser skin rejuvenation. Dr. Soni believes in a more conservative approach and his first goal is education. Clients are able to determine the ideal treatments after discussion with Dr. Soni regarding the expected outcomes, cost, as well as risks.

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